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Search Results for " 3c-like protease "

Targets Recommended: SARS-CoV

14

抑制剂 & 化合物

20

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9351	Nirmatrelvir	SARS-CoV	Microbiology/Virology
	PF-07321332 是一种有效的口服活性 SARS-CoV 3CLPRO 抑制剂，对 SARS-CoV-2 病毒有针对性，可研究 COVID-19。它是一种胰蛋白酶样蛋白酶抑制剂，可抑制气道上皮钠通道功能。
T14968	Cinanserin hydrochloride SQ 10643	Influenza Virus; 5-HT Receptor	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Cinanserin hydrochloride (SQ 10643) 是一种高亲和力拮抗剂，对 5-HT2 受体的Ki 值为 41 nM。它也是严重急性呼吸综合征冠状病毒的 3C 样蛋白酶抑制剂。
T9458	PF-00835231	SARS-CoV	Microbiology/Virology
	PF-00835231 是一种 CoV-2 半胱氨酸 3C 样蛋白酶抑制剂，对 SARS CoV-2 和 SARS CoV-1 3CLpro 的 IC50 分别为 0.27 nM 和 4 nM。它用于抗 SARS-CoV-2/COVID-19 的研究。
T70564	NPI64
	NPI64 is a broad-spectrum coronavirus protease inhibitor which inhibits viral 3C and 3C-like protease.
T71817	CID-948801
	CID-948801 is a novel 3C-like protease inhibitor of SARS-CoV-2.
T68674	Vincapusine
	Vincapusine is a natural inhibitor of 3C-like protease (3CLpro), targeting SARS-CoV-2 3CLpro, SARS-CoV 3CLpro and MERS-CoV 3CLpro.
T60962	SARS-CoV-2-IN-18
	SARS-CoV-2-IN-18 (Compound 26) 是 SARS-CoV-2 3C-样蛋白酶的有效抑制剂 (IC50 = 45 nM)。
T79866	Zevotrelvir	SARS-CoV	Microbiology/Virology
	Zevotrelvir (化合物 52)作为冠状病毒抑制剂，对229E hCoV及SARS-CoV-3CL proteases展现出的IC50值均为 <0.1 μM和 <0.1 mM。此化合物显示了对病毒感染治疗的潜在应用。
T40340	SARS-CoV-2-IN-10
	SARS-CoV-2-IN-10 is a powerful and non-toxic inhibitor of SARS-CoV-2 3CL protease, with IC50 and EC50 values of 0.13 nM and 1.03 nM, respectively. The SARS-CoV-2 3C-like protease (3CLpro) is a critical enzyme for viral replication and serves as an ideal target for intervention. By targeting the SARS-CoV-2 3CL protease, SARS-CoV-2-IN-10 has the potential to facilitate the development of effective antiviral drugs specific to SARS-CoV-2.
T72671	SARS-CoV-2-IN-12
	SARS-CoV-2-IN-12 是一种有效的 SARS-CoV-2相关 3C 样蛋白酶抑制剂 (Ki=32.1 pM)，可用于预防 SARS-CoV-2 病毒复制，用于 COVID-19 的研究。
T72364	SARS-CoV-2 3CLpro-IN-5	SARS-CoV	Microbiology/Virology
	SARS-CoV-2 3CLpro-IN-5 是一种针对 3C样蛋白酶3CLpro 的共价抑制剂，其抑制活性的 IC50 为 3.8 nM。该化合物的口服生物利用度（BA）为 9.0%，可用于 COVID-19 研究。
TMIH-0394	Nirmatrelvir-d9
	Nirmatrelvir-d9 是 Nirmatrelvir 的氘代化合物。Nirmatrelvir 的 CAS 号为 2628280-40-8。PF-07321332 是一种有效的口服活性SARS-CoV 3CLPRO抑制剂，对 SARS-CoV-2 病毒有针对性，可研究 COVID-19。它是一种胰蛋白酶样蛋白酶抑制剂，可抑制气道上皮钠通道功能。
T40341	SARS-CoV-2-IN-11
	SARS-CoV-2-IN-11 is a highly potent and non-toxic inhibitor of the 3C-like protease (3CLpro) of SARS-CoV-2, demonstrating IC50 and EC50 values of 0.17 nM and 1.45 nM, respectively. This compound targets the essential viral replication enzyme, 3CLpro, making it an attractive candidate for intervention strategies. SARS-CoV-2-IN-11 holds significant promise in the development of specific antivirals against SARS-CoV-2.
T83719	Mca-AVLQSGFR-K(Dnp)-K-NH2 TFA
	Mca-AVLQSGFR-K(Dnp)-K-NH2 是针对严重急性呼吸综合征冠状病毒(SARS-CoV)主蛋白酶(Mpro)，也称为3C样蛋白酶(3CLpro)的荧光底物。SARS-CoV Mpro 切割后，会释放7-甲氧基香豆素-4-乙酰基(Mca)，通过其荧光可以量化SARS-CoV Mpro 活性。Mca 的激发/发射波长最大值分别为328/420 nm。

化合物

Cat.No: T9351

Target: SARS-CoV

Cinanserin hydrochloride

Cat.No: T14968

Synonym: SQ 10643

Target: Influenza Virus, 5-HT Receptor

Cat.No: T9458

Target: SARS-CoV

Cat.No: T70564

Cat.No: T71817

Cat.No: T68674

SARS-CoV-2-IN-18

Cat.No: T60962

Cat.No: T79866

Target: SARS-CoV

SARS-CoV-2-IN-10

Cat.No: T40340

SARS-CoV-2-IN-12

Cat.No: T72671

SARS-CoV-2 3CLpro-IN-5

Cat.No: T72364

Target: SARS-CoV

Nirmatrelvir-d9

Cat.No: TMIH-0394

SARS-CoV-2-IN-11

Cat.No: T40341

Mca-AVLQSGFR-K(Dnp)-K-NH2 TFA

Cat.No: T83719

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01348	3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306) COVID-19,3CL Protease,M Proteinase,3C<...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306) is expressed in E. coli expression system. The predicted molecular weight is 33.8 kDa and the accession number is YP_009725301.1.
TMPJ-01449	3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant M Proteinase,3C-like Proteinase,3C	SARS-CoV-2	E. coli
	The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents. 3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant is expressed in E. coli expression system. The predicted molec...
TMPY-05752	SARS-CoV-2 3CLpro/3C-like protease Protein (His)	SARS-CoV-2	Baculovirus Insect Cells
	3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication and Coronavirus virion production, such as an RNA-dependent RNA polymerase, a helicase, ribonucleases and 3CLpro itself, from two types of polyproteins (pp1a and pp1ab). SARS-CoV 3CLpro exists as a homodimer and each protomer has an active site. SARS-CoV-2 3CLpro/3C-like protease P...
TMPK-01343	3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant 3CL-Mpro,M Proteinase,Mpro,3CL Proteas...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.8 kDa and the accession number is YP_009725301.1.
TMPK-01335	3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant M Proteinase,Mpro,3CL Protease,3C...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.80 kDa and the accession number is YP_009725301.1.
TMPK-01339	3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant 3CL-Mpro,M Proteinase,3CL Protease	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.78 kDa and the accession number is YP_009725301.1.
TMPK-01346	3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant 3CL-Mpro,Mpro,M Proteinase,3CL Proteas...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.8kDa and the accession number is YP_009725301.1.
TMPK-01342	3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant Mpro,3CL-Mpro,3CL Protease,M Prot...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.8kDa and the accession number is YP_009725301.1.
TMPK-01347	3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant 3CL-Mpro,3CL Protease,M Proteinas...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.4kDa and the accession number is YP_009725301.1.
TMPY-05727	SARS-CoV-2 3CLpro/3C-like protease Protein (His & Avi)	SARS-CoV-2	E. coli
	3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication and Coronavirus virion production, such as an RNA-dependent RNA polymerase, a helicase, ribonucleases and 3CLpro itself, from two types of polyproteins (pp1a and pp1ab). SARS-CoV 3CLpro exists as a homodimer and each protomer has an active site. SARS-CoV-2 3CLpro/3C-like protease P...
TMPJ-01448	3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His) M Proteinase,3CL Proteinase	2019-nCoV	E. coli
	The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents. 3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His) is expressed in E. coli expression system with N-6xHis t...
TMPK-01344	3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant M Proteinase,Mpro,3CL-Mpro,3CL Proteas...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.5kDa and the accession number is YP_009725301.1.
TMPK-01340	3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant 3CL-Mpro,3CL Protease,M Proteinas...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.72 kDa and the accession number is YP_009725301.1.
TMPK-01337	3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant Mpro,3CL-Mpro,3CL Protease,M Prot...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.79 kDa and the accession number is YP_009725301.1.
TMPK-01341	3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant 3CL Protease,3CL-Mpro,Mpro,M Prot...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.8 kDa and the accession number is YP_009725301.1.
TMPK-01338	3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant M Proteinase,3CL-Mpro,Mpro,3CL Proteas...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.82 kDa and the accession number is YP_009725301.1.
TMPK-01336	3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant 3CL-Mpro,3CL Protease,M Proteinas...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.80 kDa and the accession number is YP_009725301.1.
TMPK-01345	3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant 3CL-Mpro,Mpro,M Proteinase,3CL Proteas...	SARS-CoV-2	E. coli
	3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.5 kDa and the accession number is YP_009725301.1.
TMPK-01384	SARS PLpro/papain-like protease Protein (His) Papain-like Protease,PL-PRO,Replicase poly...	SARS	E. coli
	The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS PLpro/papain-like protease Protein (...
TMPK-01352	SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi) Plpro,PL2-PRO,pp1a,nsp1,Replicase polyprotein 1a,Papain-...	SARS	E. coli
	The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS-CoV-2 PLpro/papain-like protease Pro...

重组蛋白

3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306)

Cat.No: TMPK-01348

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant

Cat.No: TMPJ-01449

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 3CLpro/3C-like protease Protein (His)

Cat.No: TMPY-05752

Species: SARS-CoV-2

Expression System: Baculovirus Insect Cells

3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant

Cat.No: TMPK-01343

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant

Cat.No: TMPK-01335

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant

Cat.No: TMPK-01339

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant

Cat.No: TMPK-01346

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant

Cat.No: TMPK-01342

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant

Cat.No: TMPK-01347

Species: SARS-CoV-2

Expression System: E. coli

SARS-CoV-2 3CLpro/3C-like protease Protein (His & Avi)

Cat.No: TMPY-05727

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His)

Cat.No: TMPJ-01448

Species: 2019-nCoV

Expression System: E. coli

3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant

Cat.No: TMPK-01344

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant

Cat.No: TMPK-01340

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant

Cat.No: TMPK-01337

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant

Cat.No: TMPK-01341

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant

Cat.No: TMPK-01338

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant

Cat.No: TMPK-01336

Species: SARS-CoV-2

Expression System: E. coli

3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant

Cat.No: TMPK-01345

Species: SARS-CoV-2

Expression System: E. coli

SARS PLpro/papain-like protease Protein (His)

Cat.No: TMPK-01384

Species: SARS

Expression System: E. coli

SARS-CoV-2 PLpro/papain-like protease Protein (His & Avi)

Cat.No: TMPK-01352

Species: SARS

Expression System: E. coli

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